They typically occur in children and young adults, and are more common in males. Cytology cytology the study of the structure and function of cells cells are. Most chondroblastomas are appropriately treated by curettage. Histologic examination of the lesion disclosed a benign chondroblastoma. Fine needle aspiration cytology of chondroblastoma journal of. Malignant transformation has been seen in a small proportion of cases, with local and vascular invasion, and distant metastases. The full text of this article hosted at is unavailable due to technical difficulties. The authors have provided a general picture of the field, the details of which may be filled in by reference to the many fine sources available. Preoperative imaging revealed a large tumor arising from upper end of humerus with extensive soft tissue involvement necessitating a fore. It is thought to arise from an outgrowth of immature cartilage cells chondroblasts from secondary ossification centers, originating from the epiphyseal plate or some remnant of it.
Fineneedle aspiration biopsy of chondromyxoid fibroma. Intraoperative crush smear cytology of vertebral chondroblastoma. Preoperative imaging revealed a large tumor arising from upper end of humerus with extensive soft tissue involvement necessitating a forequarter. Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. It is possible that tumour cells may stimulate osteoclastogenesis and osteolytic destruction through the production of receptor activator of nf.
Chondroblastoma is uncommon, accounting for less than 1% of all primary bone tumors. Chondroblastoma pediatric orthopaedic society of north. While the age range is broad 283 years, most cbts are diagnosed in the second to third decade of life, with an average age of 19 to 23 years. Preoperative fine needle aspiration cytology made no definite diagnosis. We report an extreme case of massive, destructive chondroblastoma of the proximal humerus in a 9yearold girl. Although usually benign, chondroblastoma metastasizes on rare occasions, with fatal results. Chondroblastoma is a rare, giant cellrich, benign neoplasm of bone. Pdf on feb 1, 2011, s romeo and others published bone. Compact polyhedral chondroblasts with abundant pink cytoplasm and variable pigment, well defined cell borders and hyperlobulated nuclei with grooves in mineralized, chicken wire matrix that surrounds chondroblasts. A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. We use cookies to distinguish you from other users and to provide you with a better experience on our websites.
Two cases involved the temporomandibular joint, whereas the remaining one case occurred in the hip joint. The differential is that of other lesions which have a predilection for the epiphysis or apophysis see differential for an epiphyseal lesion. Pdf fine needle aspiration cytology of chondroblastoma of. In patients who are skeletally immature still growing there is always a risk of growth plate failure from the chondroblastoma since it usually grows adjacent to the growth plate and may damage it. Ncert books pdf free download for class 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, and 1 april 14, 2020 by kishen 16 comments there are many books in the market but. It characteristically arises in the epiphysis or epimetaphyseal region of long bones and has been reported to affect people of all ages with slight male predilection.
To define the characteristics of chondroblastoma at magnetic resonance mr imaging and the combination of findings that are diagnostic for chondroblastoma. Ct guided radiofrequency ablation minimally invasive approach may be indicated for selected small tumors. We report a case of diaphyseal one in a years old girl that admitted. Chondroblastoma danafarberboston childrens cancer and. This book is concerned with a discussion of the basic facts, concepts, and problems of cellular biology. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Fbqfbqfbq audiophile 31 band and band stereo graphic equalizer. Role of diagnostic cytology, collection and preparation of material for cytodiagnosis, cytopreparatory techniques of serous effusions, fixation of cytology specimens, staining methods in cytology.
We analyzed rapid romanowsky and papanicolaoustained slides with a respect to overall cellularity, the presence of hypercellular chondromyxoid fragments hcfs, nuclear atypia, cytoplasmic features, and the presence of giant cells. Chondroblastoma of the knee treated with resection and. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the temporal bone. It was difficult to differentiate using imaging information the lesion from malignant bone tumors such as osteosarcoma.
Chondroblastoma is a rare, benign cartilaginous bone tu. Following appropriate imaging and core needle biopsy, the diagnosis was confirmed histologically. Mar 17, 2004 chondroblastomas are rare epiphyseal bone tumors. The bethesda system for reporting cervical cytology. Older age of presentation for skull lesions is reported.
Chondroblastoma is a rare, locally aggressive bone tumour that causes osteolytic destruction at the epiphyseal end of the affected bone. Background and importance chondroblastoma is a benign primary. Chondroblastoma is a rare benign bone tumour, which presents as a locally destructive lesion, although metastases is not uncommon. The tumor, which developed in the skin on the left temple behind the auricle, was surgically removed. Chondroblastoma is a rare benign bone tumor, usually affecting the epiphysis of long bones such as the femur, tibia and. Case report and differential diagnosis with other soft tissue tumors, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. Reinterpretation of the socalled calcifying or chondromatous giant cell tumor. Both radiologic and histologic appearances of chondroblastomas of the patella are indistinguishable from those of chondroblastomas arising in other sites. In 1931, codman classified it as a chondromatous variant of giant cell tumors, when he described these lesions in the proximal humerus.
This is the tough, rubbery connective tissue from which most bones develop. Fine needle aspiration cytology of chondroblastoma. Chondroblastoma is a mostly benign bone neoplasm that typically affects the second decade of life and exhibits a lytic lesion in the epiphysis of long bones. From january 1987 through december 1992, 22 patients with histologically confirmed chondroblastoma and prior mr imaging examinations were seen. Wide excision but 50% recur microscopic histologic description.
Chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. Chondroblastoma is a rare primary bone tumor of young people fine needle aspiration cytology of chondroblastoma of bone. Pathology and genetics of tumours of soft tissue and bone. Nov 18, 20 chondroblastoma is a rare benign bone tumor of chondroblast origin that almost always occurs in a primary or secondary site of ossification, suggesting possible derivation from cartilage growth plates. Dec 03, 2018 a chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. Few case reports on its cytological findings have been published.
Most often, the tumors develop at the ends of the femur thighbone, tibia shinbone, or humerus upper arm bone. Who has defined chondroblastoma as a benign, cartilageproducing neoplasm usually arising in the epiphyses of. Department of pathology, adichunchanagiri institute of medical sciences, bengaluru, karnataka, india click here for. The cytologic diagnosis of chondroblastoma was confirmed on both cases by histopathology. Chondroblastoma vs clear cell chondrosarcoma radiology. In this report, we describe the first case of chondroblastoma of the clivus presenting with cranial neuropathy that was treated with endoscopic endonasal resection. Pdf chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. Ncert books pdf download 2020 for class 12, 11, 10, 9, 8. Case report with cytopathologic and histopathologic study francesco longo, md,luigi califano, md,f aldo zupi, md, ddsj and franco fulciniti, md chondroblastoma is a rare benign neoplasm of bone. Chondroblastoma is a rare type of benign noncancerous tumor that grows at the ends of the bodys long bones, close to the joints. Case report and differential diagnosis with other soft tissue tumors, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Chondroblastoma an unusual site in a young patient volume 110 issue 7 m. Chondroblastoma is a benign bone tu mour typically.
Chondroblastoma produces prostaglandins, which induce pain. Andrew horvai, in bone and soft tissue pathology, 2010. Pdf fine needle aspiration cytology of chondroblastoma. This bestselling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. This case report describes the operative management of 16yearold male with a symptomatic chondroblastoma of the distal femur with breach of the chondral surface. Age of occurrence is usually between 10 and 25 years with a male predominance.
A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. It is typically localised in the epiphyses of the long bones. Free cytology books download ebooks online textbooks. Given the location and possible involvement of the articular surface of the knee and the physical demands of this demographic this benign bone tumor and its conventional surgical treatment can be a significant source of morbidity. Chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location.
Xray showed a transverse fracture of patella with a lytic lesion occupying most of the two halves of the patella. The patient then underwent intralesional curettage and osteochondral allograft reconstruction of the defect. Chondroblastoma and clear cell chondrosarcoma core. Fluidfluid levels areoccasionally seen on images ofchondroblastomas, can simulate aneurysmal bonecysts. It is thought to arise from an outgrowth of immature cartilage cells chondroblasts from secondary ossification centers, originating from the. A reasonable differential diagnosis, including chondromalacia patella, is. Therapy for chondroblastoma consists primarily of surgical curettage. In 1942, henry l jaffe 18961979 and louis lichtenstein 19061977, american physicians and pathologists, designated this tumor as a benign chondroblastoma of bone 12. There are many different types of cartilage in the body. Clusters of round polygonal chondroblasts with oval or grooved nuclei and well defined cell borders. Pdf comprehensive cytopathology e book download read. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. At radiography chondroblastoma is an eccentric radiolucent lesion, with sharp sclerotic margin and areas of calcification, characteristically located in the epiphysis of the long bones. Local recurrence after such therapy occurs in approximately 15% of cases, 171, 173, 174 with time to recurrence ranging from 5 months to 8 years.
Chondroblastoma is a benign bone tumor which usually occurs in the epiphysis of long bones in young persons. For language access assistance, contact the ncats public information officer. Pigmented villonodular synovitis with chondroid metaplasia. B ligand rankl, which is a key molecule essential for regulating osteoclast formation and activity. A subtle, solid, adjacentmetaphyseal periosteal reaction ispresent medially. Manual for cytology pdf 44p this book covers the following topics. Chondroblastoma is uncommon, representing jess than i % of all bone tumors and approximately 3% of all benign bone tumors in the mayo clinic files.
Click download or read online button to get comprehensive cytopathology e book book now. Chondroblastoma is a rare benign primary bone tumor commonly presenting in the knee of young patients 3, 5. Chondroblastoma is a relatively rare, benign cartilaginous tumor, accounting for approximately 1% of the benign tumors of bone. Who has defined chondroblastoma as a benign, cartilageproducing neoplasm usually arising in the epiphyses of skeletally. Chondroblastoma is a rare benign bone tumor of chondroblast origin that almost always occurs in a primary or secondary site of ossification, suggesting possible derivation from cartilage growth plates. The most frequently involved body regions are the hip, knee, and shoulder. Continue reading to learn more about chondroblastoma or visit the bone and soft tissue tumor program page to learn about our expertise and treatment options for this condition. Dr daniel j bell and assoc prof frank gaillard et al. Since the past few decades fine needle aspiration cytology fnac has gained. Chondroblastoma an unusual site in a young patient the. All engineering books pdf download online, notes, materials, exam papers, mcqs for all engineering branch such as mechanical, electronics, electrical, civil, automobile, chemical, computers, mechatronic, telecommunication any all more popular books available here. Sneige ns, carrasco ch, ayala ag, murray ja, raymond ak 1990 fine needle aspiration cytology of chondroblastoma of bone. Chondroblastoma is a benign cartilage producing tumor typically affecting the epiphysis of long bones in. Is the study of cells structures and their functions a cell is an organized independent mass of protoplasm nucleus and cytoplasm which makes the basic primary structure of an organism.
Helpful features which suggest a clear cell chondrosarcoma include. At cytology, other giant cellrich tumors and tumorlike lesions such as aneurysmal bone cyst abc, giant cell tumor, and chondromyxoid fibroma fall under the. Comprehensive cytopathology e book download ebook pdf. Check out for full manual ultragraph pro fbqhd fbqhdfbqhd these are the audio inputs of the fbq. One of the most important concept in biology is that a cell is a basic structural and functional unit of living organism. Chondroblastoma is a rare neoplasm accounting for less than 1% of all bone tumors. Distinguishing between a chondroblastoma and an epiphyseal clear cell chondrosarcoma can be difficult. This report documents the cytological features of two cases of chondroblastomas diagnosed by cytology. Chondroblastoma patella presenting as a pathological. A metaphyseal periosteal reactionoccurs in 1530% ofchondroblastomas. We report a 28 yearold adult male who presented with a large swelling over the left shoulder region. Download fulltext pdf fine needle aspiration cytology of chondroblastoma of the fibula article pdf available in journal of cytology 314. Benign chondroblastoma with secondary aneurysmal bone cyst. Chrondroblastoma is a benign tumor of bone with slow and selflimited growth, 1% of all bone tumors.
Varies with time early hypercellularity, followed by necrosis, followed by fibrous or chondroid areas with occasional spindle cells. Nov 01, 2000 read cytological features of chondroblastoma. Pdf chondroblastoma is a rare, giant cellrich, benign neoplasm of bone. Webpathology is a free educational resource with 10236 high quality pathology images of benign and malignant neoplasms and related entities. Very few cases with extracortical aggressive soft tissue invasion or metastasis are reported. A massive chondroblastoma in the proximal humerus simulating. We herein describe three cases of pigmented villonodular synovitis with chondroid metaplasia. This site is like a library, use search box in the widget to get ebook that you want.
Commonly seen in the epiphyses and apophyses of long bones in adolescents and young adults. Any information contained in this pdf file is automatically generated from digital material. Chondroblastoma involving the temporal bone is rare. The official designation of a primary bone tumor as a chondroblastoma depends on the histologic finding of foci of chondroid matrix, andor ch. Bone pain is the most common presentation, and may be longstanding, but other more sitespecific complaints.
Chondroblastoma is a rare benign cartilaginous neoplasm that considered for approximately 1% of all bone tumors and characteristically emerges in the epiphysis of a long bone, especially the hummeros, femurand tibia. Benign chondroblastoma of the temporal bone otolaryngol head neck surg 1979 1979. If you have problems viewing pdf files, download the latest version of adobe reader. We describe the cytologic features of chondromyxoid fibroma in fineneedle aspiration biopsy specimens in 4 patients. We present a case of primary benign chondroblastoma cutis in a 19yearold man. Only rare cases have been reported in the diaphyseal region.
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